COMPARATIVE QUANTITATIVE STUDY OF DIFFERENT BRANDS OFAMOXICILLIN (500mg) TABLET MARKETED IN MAIDUGURI METROPOLIS, NIGERIA

Abstract

The study involves comparative quantitative study of eight (8) different brands of Amoxicillin, using UV Spectrophotometry and High Performance Liquid Chromatography. All the samples of Amoxicillin tested using UV analysis failed the test as all are above the specified range of 90-120% as stated by USP, 2007. Using the HPLC analysis, only 3 of the Amoxicillin samples passed the test, Healmox (108.3%), Barbimox (117.5%) and Cimoxil (114.98%) while Nemoxil, Amox 500, Cikamox, Climox and Lamox failed the test with 47.17%, 39.7%, 139.4%, 139.4%, and 74.5% respectively using the standard of 90-120% as specified by USP, 2007.

KEYWORDS: Amoxicillin, UV, HPLC