Effect of Telmisartan on Hippocampal Alterations Induced by Streptozocin in Male Rats

Abstract

Introduction: Basic experiments suggest that telmisartan, is unique among angiotensin receptor blockers in which it has a role in neural injury, neuroinflammation, and cognitive function by activating peroxisome proliferator activating receptor gamma (PPAR-?). The aim of the study is to investigate the potential effect of telmisartan on the hippocampal immunohistochemical markers of male rats' dementia model induced by streptozocin intracerebroventricularly (ICV).  Materials and methods: Hippocampal alterations was induced by administering streptozocin (3 mg/kg ICV) and concomitantly treated with telmisartan (3mg/kg p.o) for 4 weeks in wistar albino male rats. Biochemical parameters include MDA, GSH, TNF-? and IL-1? in brain tissue were estimated. In addition immunohistochemistry for detection of Glial fibrillary acidic protein (GFAP) and neuronal nitric oxide synthase (nNOS) expression were also estimated.Results: Administration of streptozocin(STZ) was significantly increased oxidative stress and neuroinflammation of the rat's brain. Concomitant used of telmisartan significantly attenuate oxidative stress and neuroinflammation. Conclusion: Telmisartan has beneficial effects against oxidative stress and neuroinflammation in brain tissue of rats submitted to STZ ICV.

Keywords: Telmisartan, hippocampus, oxidative stress, inflammation.