Study Specific Immunoglobulin E,G antibodies and Bacterial which Induced Asthmatics

Abstract

Background:  The study determine if infection with Bacteria triggers the production of pathogen-specific IgE  ana IgG in asthma Patients with chronic respiratory diseases which might contribute to inflammation and pathology Objective: This study aims at evaluating the parameters   immunity including   and IgE and IgG   antibodies Methods: This work was applied on 87  asthma patients  admitted to the Babylon center of asthma  and 40 apparently health controls with age range (9-60 years). Tonsils Swabs  cultures of asthma patients reveals major types of bacteria ,St.pyogens, S.aureus, M. catarrhalis ,Ps.aeruginosa, N.menengenitites H.influenzae , S.epidermidis . aureus form high rate of these isolates .  S Results:  The Immunological parameters showing that there is a significantly increased (p< 0.05) in IgE( 448.75) ) IU/ml compared  to  control group (50.11)  and  a significantly increased (p< 0.05 ) in IgG( 56.41) IU/ml compared  to  control group (29.33). a significantly increased (p< 0.05).Conclusion: IgE antibodies play a central role in allergic inflammation; therefore production of bacteria  may prove significant in the exacerbation of chronic, allergic airway diseases, thus highlighting a direct role in asthma pathogenesis.

Keywords: Asthma ,IgE Elisa, IgG Elisa, Bacterial isolate