Study the Role of Hormones and Enzymes Aspect in Sera of Iraqi Endometroitic Patients Before and After Treatment with Diphereline

Abstract

Endometriosis is a gynecological complication characterized by extra – uterine location of endometrial tissue , mainly in abdominal organs (including ovaries , bladder , intestine , kidney and in rare cases liver . Symptoms due to endometriosis may vary during the woman’s menstrual cycle as hormone levels fluctuate, in this regard , hormones play a central role in the aetiology of endometriosis since it is a disease of women in reproductive age and not usually seen in postmenopausal women. In women with endometriosis , the misplaced endometrial cells in the pelvic cavity also respond to these hormones. With the exeption of the symptomatic treatment of endometriosis associated pain , only two main suboptimal therapeutic approaches ( hormonal and invasive surgery). Diphereline is a single half dose depot Gonadotropin releasing hormone agonist (GnRHa) , which is long acting , GnRHa are a group of drugs that have been used to treat women with endometriosis for over 20 years , they are modified versions of naturally occurring hormones known as gonadotropin releasing hormones which helps to control menstrual cycle. This study have indicated the role of hormonal imbalance via the abnormalities in LH , FSH and PRO levels compared with  healthy control , also our study have revealed that liver was not affected by endometrial lesions for enrolled patients via normal levels as AST and ALT. Lastly , the non significant difference in creatinine and urea levels compared with healthy control reflect that the kidneys were not affected by endometrial tissue. On the other hand , this study highlights  Diphereline  role in enhancing  hormonal system in endometriotic patients (after treatment) , while has a negative side effect on liver and kidney via increasing of (AST and ALT) activities related to liver  and (creatinine and urea) levels related to kidneys in sera of patients compared with control.

Keywords  endometriosis: LH , FSH , PRO ,  AST ,  ALT , Diphereline.