Radio-protective Potentials of Methanolic/Aqueous Extract of Adasonia digitata and Cochorous olitorious Leaf Plant on Gamma Irradiated Male Wistar Rats

Abstract

It is no longer news that technology is eating deep as a cankerworm in the heart of human and it is pertinent to know that 90% of the world-used technological gadget are fully equipped with radiation emitting software, which upon human exposure to, generating free radicals-induce disease and several disorders such as hemorrhage induced anaemia, cancer, ischemia reperfusion diseases, diabetes, atherosclerosis and several others (Haliwell, 2000). Hence the needs to prevent, ameliorate, attenuate and cure the effects of radiation generating disorders. Some groups of rat were exposed to gamma radiation of 6Grey, generating free radicals and inducing several diseases and disorders. A. digitata and C.olitorious has been established to poses significant (p<0.05) amounts of antioxidant phytochemicals (inducers of endogenous antioxidant enzymes) such as Saponin(16.59±1.85 and 22.12±0.24),Tannins(311.98±0.01 and 287.07±0.16), Polyphenols(170.90±0.68 and 330.07±0.32),Alkaloids(81.56±0.56 and 68.65±2.05) and flavonoids(25.38±2.88 and 157.38±0.38) which is suggestive of the free radical scavenging potentials of the two plants extracts. The administration of the plant extract to rats exposed to radiation was able to attenuate and prevent the disorders, implicating the plant extracts to be radioprotective and antioxidative in potentials. The safety evaluation analysis was examined by measuring the serum ALT, AST and ALP level which was not significantly (p<0.05) different when compared to the normal control, establishing the Hepatoprotective potential of the plant extracts.

Keywords: Antioxidative, ameliorate, Free Radicals, Radiation, Hepatoprotective, Radioprotective