Visfatin Levels in Iraqi Controlled Diabetic Patients and Uncontrolled Diabetic with Cardiomyopathy

Abstract

The aim of the present study is to evaluate vifatin levels in uncontrolled diabetic patients and uncontrolled diabetic with cardiomyopathy and compare the results with healthy control. The study included ninety subjects with aged ranged (25-40)years and BMI(< 25)Kg/m² .These were which divided into three groups as follows : group 1(G1):consist of 30 individuals as healthy control group, group 2(G2),consist of 30 patients with uncontrolled diabetes mellitus (DM). Group3(G3) consist of 30 patients with uncontrolled DM, and cardiomyopathy as complication. Plasma was used in determination of fasting blood glucose(FBG) ,lipid profile[total cholesterol (TC), triglyceride (TG), high density lipoprotein(HDL), low density lipoprotein(LDL), very low density lipoprotein(VLDL)],C-reactive protein(CRP),insulin and visfatin.The results showed highly significant elevation in FBG, TC, TG, LDL, VLDL, while there are significant reduction in HDL levels when G2 compared with G1. The results, also showed significant elevation in these parameters when G3 compared with G2. The results revealed highly significant elevation in hs-CRP, insulin and visfatin  levels when comparing G2 with G1. Also significant elevation in these parameters were noticed when G3 compared withG2.In conclusion, study found that the concentration of visfatin increase in uncontrolled diabetic  patients with cardiomyopathy more than uncontrolled diabetic which indicate positive relation between visfatin and heart diseases. This study is the first of which has investigated these relationships.

Keywords: Visfatin , uncontrolled diabetic patients, uncontrolled diabetic with cardiomyopathy