Casein Grafted Maleic Anhydride Copolymer and Substituted With Procaine

Abstract

In this work, Casein as a natural polymer was modified with Maleic anhydride a grafted copolymer (A₁) ,then the substitution reaction was undergo between grafted maleic anhydride and procaine as amino drug, producing Casein grafted N- procienyl meleamic acid copolymer (A₂) as biodegradable polymers a suitable design of drug carrier for  controlled delivery of therapeutic agent to extend period of time and increase the residence time of drug in the system . The prepare new drug copolymer was characterized by FTIR spectroscopy and controlled release was studied in different pH values 1.1and 7.4 at 37C⁰ .Thermo gravemetric analysis was carried out, which indicated the thermal stability of (A₁) and (A₂).

Keywords:Casein ,Natural polymer ,Grafted copolymer .