Casein Grafted Maleic Anhydride Copolymer and Substituted With Procaine

Firyal Mohammad Ali., Sana H.Awad


In this work, Casein as a natural polymer was modified with Maleic anhydride a grafted copolymer (A1) ,then the substitution reaction was undergo between grafted maleic anhydride and procaine as amino drug, producing Casein grafted N- procienyl meleamic acid copolymer (A2) as biodegradable polymers a suitable design of drug carrier for  controlled delivery of therapeutic agent to extend period of time and increase the residence time of drug in the system . The prepare new drug copolymer was characterized by FTIR spectroscopy and controlled release was studied in different pH values 1.1and 7.4 at 37C0 .Thermo gravemetric analysis was carried out, which indicated the thermal stability of (A1) and (A2).

Keywords:Casein ,Natural polymer ,Grafted copolymer .

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ISSN (Paper)2224-3186 ISSN (Online)2225-0921

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