The Possible Role of Different Experimental Doses of Cadmium in the Damage of Architecture of Mice Kidney

Abstract

In the present investigation, 18 healthy male Swiss albino mice (weighing 30-35g) served as experimental material were divided into three groups.Each group consisting six mice. Group I was only given tap water as control during experimentation period (36 days), group II and group III were daily given a subcutaneous injection of cadmium in the form of cadmium chloride (CdCl₂) at a dose of 3mg and 6mg/Kg body weight respectively. Sections of kidneys were prepared and examined by light microscope. Histopathologicalobservations revealed marked degeneration in the architecture of the renal cortical structures (glomeruli and tubular cells) of the experimental groups (group II and group III) of mice respectively when compared to healthy control group.

Keywords: cadmium, histopathology, mice