Prolactin is a Novel Biochemical Marker in Sera of Iraqi Type-2 Diabetic Women With Metabolic Syndrome in Baghdad.

Abstract

Metabolic syndrome (MS)  is a group of clinical and biological abnormalities included risk of insulin resistance , disorders in glucose metabolism ,  abdominal obesity and abnormal lipid profile these features confer a greater risk of cardiovascular diseases . Anyway, the co-occurrence of diabetes mellitus and metabolic syndrome potentiates the cardiovascular risk associated with each of the two conditions. The present study aimed to determine a relationship between prolactin level in type -2- diabetic Iraqi women and metabolic syndrome, as well to find a relationship between prolactin level and other studied biochemical markers. seventy menopausal diabetic women with metabolic syndrome with age in range (45-50) years were enrolled in this study , and were compared with matched age control group which consisted of menopausal  women suffering from uncomplicated diabetic patients (without metabolic syndrome ). Two groups were not given any treatment ,  they  were newly diagnosed. This study highlights the role of metabolic syndrome in the abnormalities of  prolactin blood glucose , lipid profile , glycated hemoglobin and body mass index regardless the role of diabetic mellitus. Available evidence from the present study have reported that prolactin is a novel biochemical marker in sera of Iraqi menopausal type-2 diabetic women with metabolic syndrome . Moreover this study is the first highlights not only the association between lower level prolactin and metabolic syndrome in type-2 diabetic women but also the correlation between lower prolactin level and other biochemical markers ( Lipid profile , HbA_1c and BMI ) in type-2- diabetic women with metabolic syndrome .

Keywords : Prolactin . metabolic syndrome . type-2- diabetes mellitus . lipid prolile