Evaluation of ADA, IL-6 and TNF-alpha level in type 2 diabetes mellitus: with -and without hypoglycemic drugs.

Abstract

Diabetes mellitus(DM) is a major worldwide  health problem leading to markedly increase mortality and serious morbidity. Immunological disturbances involving the cell mediated immune system and improper T-lymphocyte function also contribute to the path physiology of type 2 DM.It has been reported that ADA,IL-6,and TNF-α levels  were a good marker for immunological disturbance in type 2 DM  patients.This study aims to assess and compare the level of serum ADA, IL-6 ,and TNF-α in patient of type 2 DM with and without oral hypoglycamic drugs.The study population consist of 150 subjects divided in to 3 groups:group I (50normal health controls),group II (45 type 2 DM patients with no on hypoglycemic drugs),and group Ш (55 type 2 DM patients on hypoglycemic drugs).There were a significant(p<0.001) tremendous increase in ADA,IL-6,and TNF-α levels (47.32 U/L ,29.04 pg/ml ,and 98.23 pg/ml, respectively ) in group II  than group I and group Ш. also, ADA,IL-6,and TNF-α levels were significantly(p<0.001) higher in group Ш than group I.As conclusion ,the increase in ADA,IL-6,and TNF-α levels  is a good glycemic  markers associated with type 2 DM .The intake of hypoglycaemic drugs  decrease the levels of these markers.

Key words: ADA activity , IL-6 , TNF-α , type 2 diabetes mellitus