Synergistic Effect of Propolis Extract and Antibiotics on Multi-resist Klebsiella pneumoniae Strain Isolated from Wound

Abstract

This study has been done to evaluate the in vitro activity of synergistic effect between ethanolic extracts of Propolis and 12 different antibiotic drugs against multi-resistant Klebsiella pneumoniae isolated from infected wounds; this evaluation was done by Agar well-diffusion method and Disc diffusion method.The results of this study showed that the isolation bacteria were resisted to most antibiotics which used in this experiment; especially that drugs containing β-lactam ring. Results of this study showed that alcoholic extracts of Propolis increase the inhibition zones of all antibiotics; and the sensitivity of bacteria increase by direct correlation with the increase in the concentration of alcoholic extract of Propolis.

Keywords: Synergistic effect, Propolis, Antibiotics, Multi-resistance, Klebsiella pneumoniae