Antidiabetic,Antihyperlipidaemic and Antioxidant Activity of Oxalis corniculata in Alloxan Induced Diabetic Mice

Abstract

The present study has been designed to evaluate the antidiabetic,antihyperlipidemic and antioxidative effect of oxalis cornicuata in alloxan induced diabetic mice. Diabetes was induced in swiss albino mice by administration of alloxan monohydrate (120mg/kg body weight,ip). The aqueous extract of oxalis corniculata at a dose 100mg/kg body weight was administered orally at a single dose per day to diabetes induced mice for a period of ten days. The effect of aqueous extract of oxalis corniculata on various biochemical parameters such as blood glucose, lipid profile,liver marker enzymes,lipid peroxidation, enzymic and non enzymic antioxidants were analysed. All these effects were compared with glibenclamide as a reference antidiabetic drug. Oral administration of aqueous extract of oxalis corniculata for ten days elicited significant reduction in blood glucose level, lipid parameters except HDL-c, serum enzymes and significant increase in the level of HDL-C,enzymic and non enzymic antioxidants. Treatment with aqueous extract of oxalis corniculata also reduced the TBARS levels. From the results, the aqueous extract of oxalis corniculata proves to scavenge free radical and found to posses antidiabetic,antihyperlipidemic and antioxidant property against alloxan induced diabetes mellitus.

Key words: Antidiabetic,Antihyperlipidaemic,oxalis corniculata, antioxidants.