Comparative Evaluation Study on Different Brands of Lisinopril Tablet using Hplc and Uv Spectrophotometer

Abstract

This study was undertaken with the objective of evaluating the chemical equivalence of different brands of lisinopril tablets with the use of two analytical methods which will be accurate and reproducible and to compare between the two methods. The chemical equivalence of nine (9) brands of lisinopril tablet were assessed through the use of HPLC and UV, where parameters such as the peak area and absorbance were used to determine the quantity of lisinopril. The result indicate that none of the samples contain less than 50% of the active principle (lisinopril).Also from the results obtained It can be seen that samples A, B, D.and G failed the test in both UV and HPLC while samples E, F, H and I failed the test in HPLC, only  sample C pass the test in both UV and HPLC The result showed that only one brand (sample C) was within the specified official standard for both the HPLC and UV spectroscopy.While 5 brands fall within the limit for HPLC. The HPLC method is more suitable for assay of lisinopril tablet because it is more sensitive and has an added quality of reproducibility and accuracy while UV spectroscopy is less sensitive but has an added quality of simplicity of method thus, reducing the possibility of errors during the procedure.