Preventive Effect of Anogeissus Latifolia in High Fructose Diet Induced Insulin Resistance and Metabolic Dyslipidemia

Abstract

Anogeissus latifolia (Combretaceae) has been used in traditional system of medicine in India for over many years, and widely used to enhance the immune system and against various ailments. During the last decade many in-vitro, in-vivo and analytical studies witnessed and justified the traditional claim of this plant. The study was aimed to evaluate the preventive effect of Anogeissus latifolia bark in insulin resistance and metabolic dyslipidemia induced by high fructose diet feeding in rats. At the end of the treatment period, the plasma from normal control, diabetic, reference standard and Anogeissus latifolia extract (300mg/kg) treated animals were subjected to estimation of insulin, lipid profile, liver marker enzymes and kidney function test. Anogeissus latifolia was found to attenuate insulin resistance and metabolic dyslipidemia induced by adverse effects of fructose. This study validates the traditional use and shows a possible beneficial effect of the plant in the treatment of diabetes mellitus.

Key Words: Anogeissus latifolia, High Fructose Diet, Insulin Resistance, Metabolic Disorder.