Frequency of IgG Antiphospholipid Antibodies in Iraqi Patients with Stroke

Abstract

Objective: To examine the presence of Immunoglobulin G type of anti-cardiolipin (ACL), anti-β2GPI  and antiphospholipids (aPL) antibody in Iraqi patients with cerebrovascular diseases especially ischemic stroke.

Methods: Immunoglobulin G type of antiphospholipid antibodies (beta 2-glycoprotein I [B2-GPI]), anti phosphatidyl serine, cardiolipin, anti phosphatidyl inositol and anti phosphatidic acid were ivestigated in 67 patients with ischemic stroke (aged between 20 to 90 years) during an three months period from October 2015 to January 2016 in Al-Zahra and  AL-Karama Hospitals, Wassit, Iraq. The clinical, laboratory and demographic characteristics of patients with a positive results were registered.

Results: One man and six women (seven patients, 10.49%) had increased IgG types of antiphospholipid antibodies. Increased titers of IgG for anticardiolipin was  observed in eight (11.94%) and seven (10.49%) of patients were positive to anti- β2GPI.

Conclusion: In spite of  the different studies in the Europe, elevated titers of IgG antiphospholipid antibodies present in a large number of patients can be resulted from the existence of unidentified triggering agents (poisons and infections), that are more common in developing countries in comparison to developed countries. This hypothesis still need  to more and more investigation in the future, in our country the morbidity is too high because of the repeated wars.