Microwave Assisted Rapid Synthesis, Spectroscopic Characterization, and Antimicrobial Significance of New Derivative of 1,4 Dihydropyridines

Abstract

An efficient one-pot three-component synthesis of 1,4-dihydropyridine derivatives were synthesized by a Hantzsch reaction of dehydroacetic acid with benzaldehyde or furfural by using microwave irradiation technique in basic alumina. The prepared ligands used to yield various complexes with Co(II), Ni(II), Mn(II), Cu(II), Zn(II) and Cd(II). The isolated solid compounds were elucidated by elemental analysis (C, H, N, M, Cl), physical measurements (magnetic susceptibility and molar conductance) and spectroscopy (¹H NMR, ¹³C NMR, IR, UV-visible, MS). Also, the synthesized compounds were tested against Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis) and Gram-negative bacteria (Escherichia coli, Proteus) by disc diffusion method.

Keywords: 1,4-dihydropyridine complexes, Microwave, Spectroscopic, Antibacterial activity.