Evaluation of Anti-Scl-70, Anti-Ro (SSA) Levels in Serum and Saliva of Patients with Systemic Sclerosis

Abstract

Systemic sclerosis (SSc) is one of autoimmune diseases that affected multiorgans, clinically showed that the extensive skin and internal organs fibrosis. Systemic sclerosis showed that the three basic sorts: autoimmunity, inflammation, vasculopathy. This study was design to investigate the changes of anti-topoisomerase I antibody (Scl-70) and Anti-Ro (SSA) in the whole saliva and serum of patients with SSc. There were highly significant (p< 0.001) elevation in Scl-70 antibody in serum and non-significant difference in saliva of patients with systemic sclerosis with median and mean rank (215.91, 51.80, 228.43 and 37.13 ng/ml respectively) in compares with control subject. The mean level of serum SSA in SSc patient (140.4 ± 22.67) ng/ml  that it was significant increased (p< 0.001) as well as the mean level of salivary SSA in SSc patient (145.5 ± 19.98) ng/ml  was highly significantly increased in compares with control subject.

Keywords:  Anti topoisomerase antibody (Scl-70), SSA (anti-Ro), SSc.