A comparative Between the Effects of Glycyrrhiza glabra Roots Extract and Pioglitazone on Induced Poly Cystic Ovary Syndrome in Rats.

Abstract

Study was designed to make comparison between effect of pioglitazone and Glycyrrhiza glabra extract for controlling poly cystic ovaries induced in the rats. (0.5 mg/kg) of Letrazole for 21 days was given to induce poly cystic ovaries. Thirty five rats were alienated into five groups: Group one (T1) left as control, group two (T2) was induced and  handled with distilled water, group three (T3) was induced and  handled with (300 mg /kg) of Glycyrrhiza glabra extract, group four (T4) was induced and treated with (20 mg/kg) body weight of piogiltazone, group five (T5) was induced and handled with (10mg/kg.) of piogiltazone and 150mg/kg of Glycyrrhiza glabra extract.  The oral administration of letrazole to rats caused prolong the length of hours in proestrus, metaestrus and diestrus phases, in addition to prolong in days of estrous cycle and gradual significant decrease in hours of estrus phase until to disappear in cycle four. The length estrous cycle, prostrus, metaestrus and diestrus phases in T3, T4 and T5 revealed a statistical reduce when compared with T2 and no significant variation when compared with T1 in cycle five. The length of estrus phase hours showed a significant increase in T3, T4 and T5 as compared with T2 and no significant difference as compared with the T1 in cycle five. Study concluded the Glycyrrhiza glabra had the ability in treating poly cystic ovary and lead to augment positive consequence of piogiltazone.

Keywords: Estrous cycle, Glycyrrhiza glabra, Letrazole, Pioglitazone