Aqueous Extract of Grape Leaves Effects on Liver Enzymes and Some Kidney Function Parameters in Hyperthyroidism Female Animals

Abstract

Vitis vinifera L. is kind of grape grown widely in Asia, Europe and America.It has many nutritional and pharmacological uses in the Indian traditional medicine, also by European folk healers and many other nations, for treatment of many medical conditions such as nausea , thirst , cough , constipation , smallpox , cholera, hemorrhoids and some of skin and eye diseases.In the present study, Vitis vinifera L. leaves was collected from shrub, grown in IRAQ. The aqueous leaves extract used, was prepared and evaluated for kidney functions (urea, creatinine ,uric acid) and liver enzymes  activity (AST,ALT) in induced hyperthyroidism female rabbits. Results showed significant decrease ( p<0.05) in levels and activities of the studied parameters .Our conclusion this herb may inhibits enzymes activity, that was activated by Levothyroxine  sodium. So we think there is a relation between the drug and enzymes releasing sources.

Keywords: Vistis vinifera L., L- thyroxin, Urea, Creatinine, Uric acid, AST, ALT.