Medicinal Activity of Alkaloidic Compound 1H-pyrido{2,3-b} indole Isolated from Solanum melongena Cortex Against Some Pathogenic Bacteria

Abstract

Current study was carried out for extraction ,isolation ,separation and identification of the alkaloidic compound which is represented by   (1H-pyrido{2,3-b} indole from Iraqi Solanum melongena cortex by using cold ethanolic extract ,qualitative analysis ,quantitative isolation and gas-chromatography –mass spectrum(GC-MS) technique. This active compound was applied for estimation and investigation of its medicinal activity by using various concentration agains two pathogenic bacteria which were represented by Escherichia coli and Staphylococcus aureus .the concentration (10, 15,  25. 50,  100  and 200 mg/ml),recorded inhibition zones diameters equal to b(20,21,22,21,23 and 41)against growth of E.coli bacteria strin wheras  the same concentrations showed inhibition zone diameters equal to (1.0,1.0,25,30 and 43 mm) against growth of  S.aureus bacteria strain the minimal inhibitory concentration was 0.1 gm/ml for both bacteria strains .Therefore (1H-pyrido(2,3,-b  ) indole compound  can be used for treatment of different diseases caused by these pathogenic organisms but this research demands further clinical and pharmaceutical studies .

Keywords: Solanum  melongena cortex, 1H-pyrido{2,3-b} indole ,pathogenic bacteria ,GC-Mass technique .medicinal activity .