Sensitivity of Pseudomonas Species Expressing Extended Spectrum Beta Lactamase to Different Solvent Fractions of Milletia Aboensis

Moses N Ikegbunam, Calistus D Nwakile, Malachy C Ugwu, Daniel L Ajaghaku, Charles O Esimone

Abstract


The presence of Extended Spectrum Beta Lactamase (ESBL) producing organisms in abattoirs, a non-hospital community was investigated. A total of ten (10) isolates of Pseudomonas species out of twenty-six bacteria isolates expressing ESBL was obtained. The anti-pseudomonal activities of various solvent fractions of Milletia aboensis against the ESBL positive isolates of Pseudomonas species showed varying sensitivity. These results have suggested that Milletia aboensis possess potent anti-pseudomonal agents that could be used to treat infections due to Pseudomonas species expressing ESBL. These anti-pseudomonal metabolites are located in the ethanol, chloroform and methanol fractions but are absent in the ethyl acetate fractions.

Keywords: Extended Spectrum Beta Lactamase, Milletia aboensis, Pseudomonas species


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ISSN (Paper)2224-3186 ISSN (Online)2225-0921

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