Evaluation of Hepcidin Hormone and Some Biochemical Parameters in Iraqi Children Patients with β-Thalassaemia Intermedia Before and After Blood Transfusion

Abstract

Background:"thalassaemia" refers to a group of blood diseases characterized by low or absent synthesis of normal globin chains. Depending on the chain whose synthesis is impaired, the thalassaemias are called α‒, β‒,ɣ‒ ,σ‒ or ԑɣσβ-thalassaemias . Most thalassaemias are inherited as recessive traits.Objective: the aim of this study is evaluated hepcidin levels, transferrin, ferritin, serum iron and total iron bending capacity [TIBC] before and after blood transfusion of thalassaemia patients.Methods: In this study, we take 80 persons the age of them were mean±SD (9.68±2.08), 40 patients with β-thalassaemia intermedia, and 40 healthy persons as control. We take blood 5ml from thalassaemia's patients before blood transfusion and after transfusion of blood by 3 days. The total number of the samples we taken are 120, 40 samples before blood transfusion, 40 samples after blood transfusion and 40 control samples. Then we separated each sample into two tubes.Result: increase iron absorption of thalassaemia patient after blood transfusion due to decrease level of hepcidin.Conclusion: from this study was appear iron absorption meanly affect by hepcidin level, so that hepcidin was highly significant change in thalassaemia patient after blood transfusion and that lead to iron overload. So conclude high levels of ferritin after blood transfusion due to blood uptake lead to increase iron storage (ferritin).

Keywords: β-thalassaemia intermidia, hepcidin, serum iron and ferritin (iron storage).