Anticancer activity of lactuca steriolla growing under dry desert conditionof Northern Region in Saudi Arabia

Abstract

Medicinal herbs are also significant source of synthetic and herbal drugs. So far, pharmaceutical companies have screened more than 25,000 plants for anti-cancer drugs. So  we  done  to discover the anticancer activity of the terpinoid compound isolated from terrestrial Saudi plants, the MeOH extract of the aerial parts of the plant lactuca steriolla family Asteraceae was in vitro investigated for cytotoxicity against   HCT116, A549,  HepG2 and MCF-7 cell lines, and resulted in vitro show high  cytotoxic activity against breast cancer with for MeOH extract and good cytotoxicity against    liver cancer of hexane extract, respectively, Organic extracts , were fractionated through classic chromatography. The steroids stigmasterol acetate,  ?-sitosterol and campesterol were identified in hexane extract. Triterpenes, germincol, lupeol, ?-amyrin, ?-amyrin, olean 18-ene, lupeol acetate were isolated from methanol extract.  Steroids and 14b-perganane and 4- piprdenone were isolated from methanol extract and identified by GC-MS. while triterpenes identified byH¹ NMR and C¹³NMR. Essential oils of the fresh leaves were obtained by hydro distillation and analyzed by GC-MS

Keywords: Asteraceae, Lactuca serriolla, triterpene, volatile oil, breast anticancer