Polyherbal Therapies Attenuated Diabetes Induced Liver Damage

Abstract

To evaluate glucose, liver function, lipid profile, urea, total protein, albumin, globulin and weight of liver tissues in diabetic rats. Thirteen groups of 6 rats each were used. Groups 1 and 2 Normal and Diabetic Control received 0.5 ml Dimethylsulphoxide; 3 and 4 received 5UI/Kg b.w insulin and 5mg/Kg b.w glibenclamide; 5, 6, 7 and 8  received 500 mg/Kg b.w of Vernonia amygdalina,  Moringa oleifera, Gongronema latifolium and Ocimum gratissimum extracts respectively; 9, 10 and 11 received 250 mg/ Kg b.w of M. oleifera/V. amygdalina, M. oleifera/ G. latifolium and M. oleifera/O. gratissimum respectively; 12 received 166.66mg/kg b.w of V. amygdalina/ G. latifolium/ O. gratissimum while 13 received 125mg/kg b.w of all extracts. There was reduction in liver weight, glucose, lipid profile and urea in all treated groups. Total protein, albumin, globulin and HDL-cholesterol increased in the treatment groups. Polyherbal treatments are potent at attenuating diabetes induced liver damage.

Keywords: Hepatoprotective, Moringa oleifera, Vernonia amygdalina, Gongronema latifolium, Ocimum gratissimum