A Review on Synthesis, Characterization Methods and Biological Activities of Semicarbazone, Thiosemi-Carbazone and Their Transition Metal Complexes

Abstract

Semicarbazones and thiosemicarbazones are compounds obtained by condensation of Semicarbazides and thiosemicarbazide with suitable aldehydes or ketones. They are potent intermediates for the synthesis of pharmaceutical and bioactive materials and thus, they are used extensively in the field of medicinal chemistry. The development of new beneficial bioactive compounds exhibiting different biological activities is one of the crucial aims in medicinal and bioinorganic chemistry. Semicarbazones, thiosemicarbazones and their derivatives have been evaluated as antibacterial, antifungal, antioxidant, antiviral, radical scavenging, antitubercular, antitumor and anticancer therapeutics especially when bind to transition metals. Their biological activities are considered to be related to their ability to form chelates with metals. The structures of the compounds have been characterized on the basis of their IR and 1H-NMR data. Studies have been conducted on compounds bearing –N=N-, -N-C=S, and -CH=N- as pharmacophore. Accordingly by considering this biological potential herein, the synthesis root of some of these derivatives and complexes are reviewed as for biological activities and is aim to organize the different biological activities of some synthesized semicarbazone and thiosemicarbazone derivatives with transition metals.

Keywords: Semicarbazone, thiosemicarbazones, Metal Complexes, antibacterial, antifungal and anticancer therapeutics.

DOI: 10.7176/JNSR/9-17-04

Publication date:September 30^th 2019