Relation between Hypercholesterolemia and Insulin like growth factor-1 in Elderly Women suffer from Hypothyroidism

Abstract

The present study included 40 female subjects. They were classified into two groups: group I included 20 females diagnosed as primary hypothyroidism with age ranged between 45 – 65 years and group II included 20 ages matched normal female volunteers and served as control group. Insulin like growth factor -1, (IGF-1) cholesterol, triglycerides, Thyroid stimulating hormone, thyroxine-3 (T₃) and thyroxine-4 (T₄) hormones were measured in both groups. The obtained results revealed that, there was a significant decrease in IGF-1 level in group I, when compared to control group (P ? 0.01). Correlation studies showed that IGF-1 is strongly positively correlated with T₃ (R=0.81, P ? 0.01) and moderately positively correlated with T₄ (R= 0.58, P ? 0.05). Meanwhile, it was moderately negatively correlated with cholesterol (R= 0.6, P ? 0.05). The results indicate that IGF-1 deficiency in elder women suffering from ?hypothyroidism may have a direct relation in the pathogenesis of hypercholesterolemia.

Keywords: Hypercholesterolemia: Insulin like growth factor -1: Elderly: Hypothyroidism: growth hormone: thyroid hormone: cholesterol.