Effect of Aqueous-Methanol Leave Extract of Cassia Occidentalis on CCl4 Induced Hepatotoxic Rabbits

Abstract

The use of the different part of Cassia occidentalis in treatment of several deseases has lead to the several researches about the plant capability in desease prevention and curation. This research investigates the effects of aqueous methanol leaves extract of Cassia occidentalis on most of the liver function indices (ALT, AST, ALP, T.BIL, D.BIL, T.P, Albumin, Globulin) in carbon tetrachloride induced hepatotoxicity. A total of fifteen rabbits were used for the research, which were divided into five groups (GroupI to V) three rabbits per each group. Group I served as normal control, Group II served as test control, Group III, IV and V were induced with hepatic toxicity and administered with the extract at a dose of 50mg/kg, 100mg/kg and 10mg/kg of livolin respectively, per day for two weeks. A significant decrease (p<0.05) in liver function indices was observed in all groups compared to test control. Administration of the extract lead to a significant decrease (p<0.05) in liver function indices in a dose dependent manner compared to test control. Similar pattern of activity was observed between 50mg/kg of the extract and 10mg/kg of livolin (standard drug) in hepatocurative activity. The observed hepatocurative ability of the plant may be due to the presence of phytochemicals.

Keywords: Cassia occidentalis; Carbon Tetrachloride; Aqueous-Methanol and Hepatoxocity.

DOI: 10.7176/JNSR/12-10-05

Publication date:May 31^st 2021