The Anti-Inflammatory and Antioxidant Effects of Methanol Seed Extracts of Sunflower (Helianthus annuus) and Level of Uric Acid in Gout Induced Albino Rats

Abstract

The seeds of Helianthus annuus (H. annuus) are known for their economic importance, especially in vegetable oil production. The work aimed to study the anti-inflammatory and antioxidant effects of methanol seed extracts of H. annuus and the level of uric acid in gout-induced Albino rats. In an experiment, using monosodium urate (3mg/kg), gouty arthritis was induced on the left-leg ankle of the albino rats subcutaneously and three different concentrations of the seed extracts; 250, 350, and 450 mg/body-weight used to fed the induced rats; D, E and F groups, and C group were given allopurinol (positive control), while B and A groups were negative and normal controls. In a dose-dependent pattern, methanol seed extracts increased the activity of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPX). Furthermore, it significantly decrease the level of uric acid, Interleukin 6 (Ile 6), and xanthine oxidase activity (p<0.05) in the treated groups. These makers are involved in oxidative and inflammatory processes that cause pains in gouty arthritis. The study suggests that the methanol seed extracts have antioxidants and anti-inflammatory potential against gouty arthritis in albino rats.

Keywords: gouty arthritis, anti-inflammatory, antioxidants, ROS, Helianthus annuus seed.

DOI: 10.7176/JNSR/13-6-03

Publication date:March 31^st 2022