Recent Developments in Nuclear Medicine Applications of Radiolabeled Nanocarriers

Abstract

Advances in nanotechnology have increased the use of polymers with modifiable properties in the development of drug delivery systems. In the development of more effective radiopharmaceuticals which can be used especially in imaging and treatment, the application of nanoparticles that composed of polymeric systems has gained importance today. Synthetic polymers such as poly ethylene oxide (PEO), poly glutamic acid (PGA) and poly lacticoglycolic acid (PLGA) are examples of polymers suitable for clinical use and used in the development of nanocarriers. Liposomes, micelles, polymerosomes and nanoemulsions are referred to as nanoparticle systems composed of polymeric systems. These systems are more localized in the desired tissue due to the increased permeation and retention effect (EPR), and increase the effectiveness in treatment and diagnosis. In this review, the studies on the use of polymers used in imaging and treatment and the applications of nuclear medicine in the nanoparticle systems prepared with these polymers will be evaluated.

Key words: Polymer, Radiolabeling, Nanotechnology, Nuclear Medicine