Synthesis of Disulfiram Imprinted Polymer and Electrochemical Application

Abstract

Molecular imprinting has become a powerful tool for the preparation of three dimensional polymeric materials with special recognition ability. The three dimensionally cross-linked polymeric materials are obtained by polymerization of functional monomers in the presence of template molecule. Then, leaching of template molecules by a leaching procedure generates the recognition cavities complementary to the shape, size and functional groups of the template molecules. Thus, molecularly imprinted polymers are often used because of their stability, their resistance to temperature and pressure, resistance to effects of the chemicals and their re-use, as well as their selective properties against template molecule. Nowadays, molecular imprinting technique has been successfully assembled with a several of analytical techniques in chromatography, sensor etc. In this study, disulfiram imprinted microbeads were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM). A carbon paste electrode (CPE) was modified with disulfiram molecular imprinted polymer (MIP) and used for the determination of disulfiram in active substance of pharmaceutical sample by Differential Pulse Voltammetry (DPV).

Keywords: Disulfiram, Electrochemical sensor, molecularly imprinted polymer, Carbon paste electrode