Effects of Cardiopulmonary Bypass Temperature and Time on Inflammatory Response

Abstract

Background: To investigate the effect of cardiopulmonary bypass temperature and duration on inflammatory response in patients undergoing open heart surgery. Methods: The study group consisted of 43 patients and the patients were divided into two groups. Group 1 (n: 17) was operated using hypothermic bypass and group 2 (n: 26) was operated using normothermic bypass. Blood samples were taken for CRP, IL-6, IL-10 and TNF-α levels in the preoperative and postoperative period. Results: The demographic and preoperative characteristics of the patients were similar. The CRP level was significantly higher in the normothermic group than in the hypothermic group (Group 1: 92.2 ± 36.36, Group2: 120.58 ± 47.55) (p <0.05). In both groups, TNF-α, IL-6 and IL- No statistically significant difference was found in 10 values. (p> 0.05) When we evaluated the effect of CPB duration on inflammatory response, one unit change in aortic cross clamp duration increased IL-10 by 0.175 fold (p = 0.042 <0.05). The operation time was 10% significant. It was observed that 1 unit increase in the duration of operation increased the IL-6 level by 0.203 fold. (P <0.05) Conclusion: According to these results, it was seen that there was no significant difference in normothermic and hypothermic CPB patients, but prolonged operation time and aortic cross clamp duration increased inflammatory response.

Key words: Cardiopulmonary bypass, hypothermia, inflammatory response, cytokine, open heart surgery

DOI: 10.7176/JSTR/5-2-35