The Relationship between Magnesium Level with Glucose Regulation and Amount of Proteinuria in Type 2 Diabetes

Abstract

Diabetes Mellitus is a globally common, chronic metabolic disease. In progression of disease itself, peripheral insülin resistance and insülin secretion disorders can be observed. In addition there can be electrolyte disorders such as magnesium, calcium and iron deficiency. Magnesium levels may have significant role in the clinical course of the disease. In this study, it is aimed to observe relationship among magnesium levels glucose regulation and proteinuria. In this cross sectional study, 200 diabetic patients were examined for magnesium levels. Blood parameters and proteinuria levels were determined and the patients were divided into two groups as hypomagnesemic and normomagnesemic. Glucose levels, HbA1c and proteinuria levels were compared between groups. Of the cases (n=200), 59 (29.5 %) were male and 141 (70.5 %) were female. The frequency of hypomagnesemia was 38.5 %. The incidence of hypomagnesemia in women (46.1 %) was significantly higher than in men (20.3 %) (p=0.001). In hypomagnesemia group, glucose level (179.7 ± 60.2 mg/dL) was higher than normomagnesemia group (160.7 ± 52 mg/dL) (p=0.013). However, no statistically significant difference was observed between the groups in terms of HbA1c level. Proteinuria levels were higher in hypomagnesemia group (0.18 ±0.12 mg/mg) than normomagnesemia group (0.14±0.05 mg/mg) (p=0.013). Magnesium deficiency is a common condition in diabetic patiens and may have negative effects on glucose regulation and proteinuria. Randomized controlled trials are needed to clarify the role of magnesium in diabetic complications.

Keywords: Diabetes Mellitus, magnesium, proteinuria

DOI: 10.7176/JSTR/5-10-02