Examination Subclinical Inflammatory Markers and Plasma Neutrophil Gelatinase-Associated Lipocalin in Obsessive-Compulsive Disorder

Abstract

Background: Inflammation has a role in the etiopathogenesis of obsessive-compulsive disorder (OCD). Aims: We investigated the relationship of disease and disease severity with plasma neutrophil gelatinase-associated lipocalin (NGAL) level, and subclinical hemogram parameters in patients new diagnosed OCD. Methods: A total of 39,654 patients who presented to the ambulant psychiatry outpatient clinic, diagnosed a psychiatric diseases between January 2018 and October 2020 were evaluated DSM-5 criteria; 54 patients who were new diagnosis OCD included in the study. The hemogram was evaluated platelet (PLT) count, PLT–lymphocyte ratio (PLR), PLT- distribution witdth (PDW), neutrophil–lymphocyte ratio (NLR), C-reactive protein (CRP), and NGAL levels were analyzed in relation to an inflammatory condition. Results: A significant difference was found between disease severity and the PLT count, PDW, and NGAL values. PDW and NGAL values have relationship with disease severity by linear regression analysis. A significant difference was found the OCD with higher CRP, PDW, and a lower PLT value and showed a relationship between the PDW value by ROC analysis. Conclusion: This study was novel in reporting a significant relationship between the PDW level and the disease, and between the PDW and NGAL levels and disease severity in patients diagnosed with OCD.

Keywords: CRP, NGAL, OCD, PDW, platelet count

Special Issue of Health Sciences

DOI: 10.7176/JSTR/7-08-04