A Mathematical model for the effect of Gastrin in humans using Fuzzy Rayleigh distribution

Abstract

Gastrin is a potent stimulant of lower esophageal sphincter pressure in human. Several observations suggest that lower esophageal sphincter pressure is under the control of gastrin concentration. Injections of gastrin produce a marked increase in lower esophageal sphincter pressure. Various doses of synthetic gastrin-I significantly increased lower esophageal sphincter pressure. In this paper, we developed a mathematical model using the fuzzy Rayleigh distribution for the effects of gastrin on lower esophageal sphincter pressure in humans.

Key Words: Cumulative damage model, Rayleigh distribution, Gastrin.