Stability Criterion of Periodic Oscillations in a Mathematical Model of CTL Response to HIV Infection

Abstract

With the continuing absence of HIV/AIDS cure, the current use of HAART (Highly Active AntiretroviralTherapy) has remained the only feasible control measure. Although it does not eradicate the disease completely, itmaintains low viral load helping reduce infectivity of exposed individuals. The time lag between the cause (action of HIVvirus) and the effect (reaction of the immune system) leads to periodic solutions representing oscillatory cell populations. Inthis paper we analyze a mathematical model that describes the dynamics of the immune system and a drug sensitive wildtypeHIV variant. More information of the article can be found in the full paper.