Antitcancer effect and Seasonal variation in oil constituents of Santolina chamaecyparissus

Abstract

The volatile components of the aerial parts of Santolina chamaecyparissus, an aromatic plant of North region, Saudi Arabia, were analyzed in two season by GC and GC-MS. Among the 39 compounds identified, major components were Curcumene, alpha-terpinol, p-cymene, 1,8-cineole and caryophllene oxide. Quantitative variations have been characterized following the season. Oil extract of the aerial parts of the medicinal plant Santolina, was in vitro investigated for cytotoxicity against A549,  HCT116, HepG2 and MCF-7 cell lines, and resulted show high cytotoxic activity against  HepG2 with (97.7 %), but resistance to other cell lines, The percentages of inhibition related to the reference drug (doxorubicin),  as long as people are looking to alternative forms of medicine and relaxation such as aromatherapy in this review we confirm the use of one of these medicinal plant as  antitumor agent.

Keywords: S. chamaecyparissus, volatile oil , anticancer, Caryophyllene oxide