Synthesis & Study of Anesthesia Organic Compounds

Abstract

In the  present work , mono & bicyclic compounds [1-8] were synthesized as  derivatives of analagisic by alkalytion of 2-aminothiozoline with carbonyl compounds (succinic acid ., chloro aceticacid .,2,5-hexan-dione ., 3-chloro propoyl chloride ), where as the compounds [9-12] were synthesized by condensation between diketone compounds with (2-amino benzothiazole ,guanine) . The synthesized compounds structures were characarterized by several methods :{(C.H.N)-analysis , FT.IR-spectra , ¹H.NMR-spectra } & melting points .

Keyword: Anesthesia , pharmaceiutical compounds ., diketone

Introduction :

Asystematic investigation of this class of compounds lead revealed  that thiazol containing pharmacoactive agents play important role in medicinal chemistry and has a long history of application in agrochemicals and pharmaceiuticals industry as a analgesic and anti-inflammatory drugs are prescribed simultaneously in normal practice.

The target compounds constitute an essential pharmacophore in many naturally occurring and biologically active agents.Thiazoles fused with different compounds that are known to contribut as antitumor and antimicrobial^(1,2).

The mono & bicyclic compounds are class of compounds well known for along time as anesthetic drugsin surgery such as diazepine compounds^(3-5)which were first introduced for the treatment of anxiety ^(4-6) .

In this study , the synthesized compounds (thiazolo diazepine , benzoimidazol, thiazolo pyrimidone ,benzothiazolo pyrimidine , guano pyrimidine ) are cyclic compounds in which one or more of nitrogen atoms which contain five , six & seven membered unsaturated rings of mono or bicyclic compounds ^(3,5) .

In this work , the cyclic nitrogen compounds were synthesized by cyclocondensation of amino compounds with carbonyl compounds led to formation of mono & bicyclic compounds   [1-12] , which used as analgesic , relaxative , hypnotic^(7,8)& other uses^(9-20) .