Synthesis , Characterization and Antibacterial Activities of Co (II),Ni(II),Cu(II),Zn(II),Cd(II)and Hg(II) Mixed-Ligand Complexes of L-Proline and Trimethoprim antibiotic

Abstract

The Co(II), Ni(II) ,Cu(II), Zn(II) ,Cd(II) and Hg(II) complexes of mixed of amino acid  (L-Proline ) and Trimethoprim antibiotic were synthesized. The complexes were characterized using solubility, melting  point, conductivity measurement   ,. and determination  the percentage of  the metal  in  the  complexes  by  flame(AAS).Magnetic susceptibility, Spectroscopic Method [FT-IR and UV-Vis].    Draw the proposed structure of the complexes using program ,  Chem. office 3D(2006). The   ligands   and  there metal complexes were  screened  for  their antimicrobial activity against  four bacteria (gram + ve) and (gram -ve){Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus}.The proposed structure of the complexes using program , Chem office 3D(2006).The general formula have been given for the prepared mixed ligand complexes   [M(Pro)₂(TMP)(H₂O)]where   L-Proline (abbreviated as  (ProH ) = C₅H₉NO₂ And   Pro^- = C₅H₈NO₂ deprotonated  primary ligand, L-proline  . Trimethoprim (abbreviated as  (TMP ) =C₁₀H₁₁N₃O₃S .

Keywords: Trimethoprim antibiotic, L-Proline   , Spectral and antibacterial activities.