The Role of Vitamin D against to Lung Damage on Infected Mice by Mycobacterium tuberculosis

Abstract

Tubercolosis disease eradication efforts in Indonesia have been carried out using a strategy Directly Observed Treatment Short-Course (DOTS) to free treatment, but prevention and eradication is still not satisfactory. The sample consisted of 24 mice were divided randomly into two groups, one group was given oral vitamin D through 100ng of each mouse each day and the other group did not receive vitamin D, then each group was randomly divided into two groups were fed a vitamin D were infected with Mycobacterium tuberculosis and one group who did not receive vitamin D were infected with Mycobacterium tuberculosis.  b, IL-12 and Nfk-gat -14 in the week to check the levels of IFN-. ANOVA test was used to see the difference in vitamin D given to those not given vitamin D with p <0.05, there is an increase in levels of IL-12, p = 0.001 but no elevated levels of IFN-b. The results showed no effect of vitamin D increased expression Nfk- and results of research into the effects of infection with Mycobacterium tuberculosis found no elevated levels of IL-12, p = 0.00, but no increase in levels of IFN-? and-? expression Nfk. Results of research into the effects of Vitamin D and Mycobacterium tuberculosis infection found no elevated levels of IFN-? p = 0.043, but no increase in levels of IL-12, and Nfk-? expression  and decreased granuloma process, but not an increase in the expression of Nfk-? and IL-12. g Effect of vitamin D can increase the cellular immune response by increasing IFN- probable cause is the increasing Nfk-? expression induced by vitamin D due to increased transcription in the nucleus of cells that signal the cell nucleus to increase the production of IL-12. Then IL-12 increases Th1 response to produce IFN-?, increased IFN-? production and activates macrophages to kill Mycobacterium tuberculosis.

Keywords: Vitamin D, Mycobacterium tuberculosis