Synthesis, Physico-Chemical and Antimicrobial Activities Co(II),Ni (II) ,Cu(II), Zn(II),Cd(II) and Hg(II) Mixed- Ligand Complexes of L- Alanine and Trimethoprim Antibiotic

Abstract

The Co (II), Ni (II) ,Cu(II), Zn(II) ,Cd(II) and Hg(II) complexes of mixed of amino acid (L-Alanine ) and Trimethoprim antibiotic were synthesized.

The complexes were characterized using melting point, conductivity measurement and determination the percentage of the metal in the complexes by flame (AAS). Magnetic susceptibility, Spectroscopic Method [FT-IR and UV-Vis].

The general formula have been given for the prepared mixed ligand complexes

[M(Ala)₂₍TMP)(H₂O)]

where  L- alanine (abbreviated as (Ala ) = (C₅H₉NO₂)

deprotonated primary ligand, L- Alanine ion .= (C₅H₈NO₂^-)

Trimethoprim (abbreviated as  (TMP ) = C₁₀H₁₁N₃O₃S

M(II) = Co (II),Ni(II) ,Cu(II), Zn(II) ,Cd(II) and Hg(II).

The results showed that the deprotonated L- Alanine by KOH (Ala- K+) act as

uni nagative bi dentate  ligand , was coordinated to the metal ions through the oxygen of the carboxylic group (-COO^-), and the nitrogen of the amine group (-NH₂) while Trimethoprim antibiotic act as  mono dentate ligand , was coordinated to the metal ions through the nitrogen of the pyrimidine group.

Keywords: Trimethoprim antibiotics , L- Alanine) complexes & Antibacterial activity