Eco-friendly Synthesis of Coumarin Derivatives via Pechmann Condensation Using Heterogeneous Catalysis

Fadia AL-haj hussien, Jomaa Merza, Ayman Karam

Abstract


A coumarin derivatives has been synthesized via Pechmann condensation naphthol with a β-ketoester using Amberlyst-15 as a green and efficient catalyst.The optimal conditions are: molar ration of reagents (1:1), Amberlyst-15 (10mol.%, 0.2 g) at 110°C for 150min. in solvent-free conditions. The recyclability of amberlyst 15 adds an advantage to the studied reaction.These coumarins derivatives have biological activity and momentousness in the industrial fields

Keywords: Coumarins, Phenols, β-Ketoesters, Pechmann Reaction,  Amberlyst-15


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ISSN (Paper)2224-3224 ISSN (Online)2225-0956

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