Coordination Modes of a New Ligand Derived from Pyrazoline with Cr(III), Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) Metal Ions; Synthesis, Identification and Biological Studies

Abstract

The solid complexes of Cr(III), Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with 2-[5-(2-hydroxy phenyl) 1,3,4-oxadiazol-2yl]-5-methyl-2, 4 dihydro-3H-pyrazol-3-one] have been synthesized and characterized by elemental analysis, molar conductance, magnetic susceptibility, UV-Visible spectroscopy. The FT-IR data suggest that the ligand behaves as a neutral bidentate with NO donor atoms sequence towards central metal ion. The microanalytical data reveals the stereochemistry of the complexes has been found to be 1:1(metal:ligand) except that of Ni(II) complex which is formed in1:2 ratio. The physicochemical data suggest the octahedral geometry for all complexes except for Ni(II) and Zn(II) complex which were square planner and tetrahedral respectively.

The ligand (L) and its metal complexes were screened for their antibacterial activity against E-coli and Bascillus microorganisms andfungicidal activity againstAspergillusnigar and Candida albicans with respect to standard antibiotic drugs tetracycline and Amphoteriain

Keywords: Pyrazol and Oxadiazol complexes.