The Chemical Chelates and a Comparative Antimicrobial Study on Some Ciprofloxacin Complexes, Spectral, Kinetic and Molecular Modeling Investigations

Abstract

A series of ciproH antibiotic drug complexes was prepared. Cu(II), VO(II), Pd(II), Zn(II), Pt(II) and Pt(IV) are the metal ions used for the preparations. The chosen ions have a great history in the medicinal field which may introduce a sensitive antibiotic appearance in comparing with the free ciproH drug. All the prepared complexes are discussed briefly based on spectral ( IR, ¹HNMR, ¹³CNMR, Uv-Vis, ESR, X- ray and SEM), thermal and analytical data. The ligand coordinates through its zwitterionic form as bidentate mod through COO^- and C=O groups. The octahedral stereo structure was prepared with Cu(II), Zn(II) and Pt(IV) ions, square planer with Pd(II) and Pt(II) ions however, the square – pyramidal with VO(II) ion. The amorphous nature was proposed for all investigated complexes based on the x- ray diffraction patterns although, the nanocrystalline appearance of starting ligand. Thermogravimetric analysis is also used to support the presence or absence of solvent molecules conjugated with the complexes isolated physically or chemically. Applying Chem- office program a suitable modeling structure of each investigated complex was drawn. A comparative antibacterial study was concerned using Gramm –ve and Gramm +ve bacteria . The data reflect the inhibiting effect of some complexes more than the drug itself which is considered an introductory step in introducing competitive drug.

Key words: ciprofloxacin complexes, spectral, modeling and biological activity