Synthesis of Poly (Acryl Lactate) with Ampicillin

Abstract

Lactic acid was used as di functional spacer could esterified with poly acrylic acid gave its corresponding ester derivative with remain the carboxylic acid of lactate unit which reacted with amino group of Ampicillin forming amide attachment, the prepared prodrug polymer have many improvement, it could enhanced the prodrug with easier hydrolysis through ester- amide groups with extended the arm pendant substituted drug, the modification percentage test was carried out, also it was characterized by FTIR and ¹H-NMR spectroscopies. Controlled drug release was studied in different pH values at 37℃. High thermal stability of the drug polymer was observed by TG and DTG indicated the protection of drug with longer date.

Keywords: Lactic acid, poly acrylic acid, Ampicillin.