Investigation on Phagocytosis Index & Humoral Immunity in Patients of Type 1Diabetes in Thi-Qar Province

Abstract

The current study was conducted at the Center for Diabetes and Endocrinology of the Health Directorate in Thi- Qar province, during the period from October 2013 to May 2014. The study aimed and evaluate immune status of diabetes type I patients by measuring the levels of  immunoglobulins ( IgM, IgG, IgA ) by single redial immune diffusion (SRID) and the study included test  phagocytic cells on phagocytosis (coefficient  of phagocytosis) and measurement hematological parameters(red blood cells count , hemoglobin, packed cell volume and count the total and differential white blood cells) . The study included a total of 100 patients with type I diabetes (51 males) and (49 females) and  there aged between 1-40 years. Levels were measured in serum immunoglobulins  for 20 a sample of patients with type I diabetes, also examined the levels of immunoglobulins  in the serum of 10 samples from healthy people in the control group. The results of the statistical analysis showed high significant increase  (P ≤ 0.001) in the immunoglobulins in  serum IgM,, IgG IgA in patients with type I diabetes compared with healthy control group . Decrease coefficient phagocytosis was significantly (P ≤ 0.001) in all patients with diabetes mellitus type I compared a group of control, either with respect to the hematological parameters  have explained the results of the current study, the lack of significant differences( P ≤ 0.05) in the rates of the values ​​of the RBCs and Hb and PCV in all patients diabetes type I, compared with the control group, also increased the rate of counting the total of WBCs and count differential cell lymphocytes, eosinophil , basophil, and monocyte  (P ≤ 0.001) in patients with diabetes mellitus type I compared with healthy people in the control group .

Key words : T1DM , IgG, IgM, IgA, Phagocytosis, lymphocytes, WBCs count , PCV