Assessment of Thyroid Function in Infertile Iraqi Females

Abstract

Infertility is one of the medical, social and psychological burdens in Iraqi society. Thyroid dysfunction can lead to menstrual disturbance, anovulatory cycle and decreased fertility. The study was designed to evaluate the role of thyroid disorders in infertility with emphasis on autoimmunity by Measuring T3, T4, TSH, & anti Thyroid peroxidase antibody in infertile females comparing the results with matching fertile controls. The study was conducted during the period from March 2015 to September 2015 at Karbala Maternity Hospital, infertility unit, and some private clinics. This study included a total number of 143 women in the reproductive age; ranging between (15- 43) years; divided into: The patients group included 92 infertile females; while controls were 51fertile females. The following parameters were measured for all study groups: T3, T4, TSH, &anti-TPO using ELISA device. The results showed that there were 60.8% of patients with primary infertility (n =56) while 38.2% were with secondary infertility (n= 36). There was a significant difference in T3, and Anti-TPO between patients and controls being higher in patients; (p-value <0.05). In addition; Anti-TPO level was significantly higher in secondary infertile patients compared to primary infertile patients. In conclusion; Thyroid disorders are closely related to infertility in Iraqi females; and Anti-TPO may be used as a biochemical indicator of subclinical thyroid disorders and may help in assessment of thyroid function as a cause of infertility whether primary or secondary.

Keywords: Infertility, Thyroid disease, T3, T4, Anti-TPO