Lack Evidence Between CTLA-4 Gene Polymorphisms Among Rheumatoid Arthritis Patients

Abstract

Rheumatoid arthritis is a chronic inflammatory disorder that typically affects the small joints in hands and feet. Genes involved in T-cell regulation are potential candidates. Association to cytotoxic T-lymphocyte-associated-4 (CTLA-4) protein, a negative regulator of T-cell activation, has previously been described in Rheumatoid arthritis patients. In this study, our aim was to determine the role of CTLA-4 polymorphism among patients with Rheumatoid arthritis. A total of 120 Rheumatoid arthritis patients (69 males and 51 females) with an age mean ± SD (67.2000± 11.74133), family history (16 positive/ 104 negative), rheumatoid factor test (RF) (43 positive/ 77 negative), Anti-CCP antibody test (120 positive/ 0 negative), and 120 controls (46 males and 74 females) of Iraqis ethnicity with an age mean ± SD (31.6583± 11.51579). There was no significant difference between the groups (Rheumatoid arthritis patients and their control) (P = 0.478). And CTLA-4 gene polymorphism in each group was compared (AA, GG, AG). There is no difference between the CTLA-4 (SNP +49 A/G rs#231775) gene polymorphism among Rheumatoid arthritis patients and healthy people.

Keywords: CTLA-4, Genotype, Rheumatoid arthritis, Genetic susceptibility, SNP