Aminophylline, Adenosine Antagonist Attenuates Glycerol-Induced Acute Renal Failure in Rats

Sabah Al-Thamir, Hamoudi Mousah, Ali Aldallal


we investigate the effect of Aminophylline against acute renal failure (ARF) in female Albino Wister rats.

ARF was produced by glycerol as a simple method for induction ARF so this achieved by injection of glycerol as single dose (10ml/kg, 50%V/V with tap water, IM) in rats which were restricted to drinking water for 24 hours. Aminophylline (5mg/rat I.P) was administered as a single dose at (60min.'s) before ARF. The blood urea nitrogen (BUN) and serum creatinine (Scr) concentrations were markedly elevated in glycerol-ARF group on the 1st day and 3rdday, but the elevation was significantly suppressed by Aminophylline. Also Aminophylline markedly attenuated the severe impairment of creatinine clearance (Crcl) caused by glycerol.

Conclusion: These findings suggest that Aminophylline can protect the renal damage caused by glycerol.

Key words: ARF, glycerol, Aminophylline.

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ISSN (Paper)2224-7181 ISSN (Online)2225-062X

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