Advances in Life Science and Technology
Aminophylline, Adenosine Antagonist Attenuates Glycerol-Induced Acute Renal Failure in Rats
Abstract
we investigate the effect of Aminophylline against acute renal failure (ARF) in female Albino Wister rats.
ARF was produced by glycerol as a simple method for induction ARF so this achieved by injection of glycerol as single dose (10ml/kg, 50%V/V with tap water, IM) in rats which were restricted to drinking water for 24 hours. Aminophylline (5mg/rat I.P) was administered as a single dose at (60min.'s) before ARF. The blood urea nitrogen (BUN) and serum creatinine (Scr) concentrations were markedly elevated in glycerol-ARF group on the 1st day and 3rdday, but the elevation was significantly suppressed by Aminophylline. Also Aminophylline markedly attenuated the severe impairment of creatinine clearance (Crcl) caused by glycerol.
Conclusion: These findings suggest that Aminophylline can protect the renal damage caused by glycerol.
Key words: ARF, glycerol, Aminophylline.
To list your conference here. Please contact the administrator of this platform.
Paper submission email: ALST@iiste.org
ISSN (Paper)2224-7181 ISSN (Online)2225-062X
Please add our address "contact@iiste.org" into your email contact list.
This journal follows ISO 9001 management standard and licensed under a Creative Commons Attribution 3.0 License.
Copyright © www.iiste.org