A Single Nucleotide Polymorphism in Interleukin–10 Gene SNP-819 Associated with Type 2 Diabetes Mellitus

Abstract

Type 2 diabetes is a multifactorial disease caused by a complex interplay of multiple genetic variants and many environmental factors. With the recent genome-wide association (GWA) studies, the number of replicated common genetic variants associated with type 2 diabetes has rapidly increased. In this study, our aim was to determine the role of IL-10 polymorphism among patients with T2DM. A total of 120 Type 2 diabetes mellitus patients (67 males and 53 females) with an age mean ± SD (62.8333± 9.46052), FBS mean ± SD (310.0000± 88.90737), family history (90 positive/ 30 negative to family history, Hypertension (86 positive/ 34 negative) and 120 non-diabetic controls (46 males and 74 females) of Iraqis ethnicity with an age mean ± SD (31.6583± 11.51579). There was significant difference between the groups (T2DM patients and their control) (P = 0.001). And IL-10 gene polymorphism in each group was compared (CC, TT, CT). There is an association between the IL-10 (SNP rs 3021097 (C/T) gene polymorphism among T2DM patients and healthy people.

Keywords: IL-10, Genotype, T2DM, Genetic susceptibility, SNP